Reduction in skin / systemic parasite burdens as a combined 1 effect of topical paromomycin and oral miltefosine treatment 2 of mice experimentally infected with Leishmania 3 ( Leishmania ) amazonensis 4 5
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چکیده
3 Newton Paiva University Center, Belo Horizonte, Brazil; 12 13 *Corresponding author at: 14 Av Antônio Carlos, 6627, Faculty of Pharmacy, Department of Pharmaceutics, Campus 15 Pampulha UFMG. CEP 31270-901. Belo Horizonte (MG) Brazil. 16 Tel.: +55 31 34096939; Fax: + 55 31 3409-6830. 17 E-mail address: [email protected] 18 19
منابع مشابه
Reductions in skin and systemic parasite burdens as a combined effect of topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) amazonensis.
This study aimed to investigate the activity of a combination of topical paromomycin gel and oral miltefosine for the treatment of experimental cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. The efficacy of the combination, evaluated by measuring lesion size and parasite burden in the skin and spleen, was assessed in BALB/c mice infected by L. (L.) amazonensis. The milte...
متن کاملEfficacy of orally administered 2-substituted quinolines in experimental murine cutaneous and visceral leishmaniases.
We report in this study the in vivo efficacy of nine 2-substituted quinolines on the Leishmania amazonensis cutaneous infection murine model and on the Leishmania infantum and Leishmania donovani visceral infection murine models. In the case of the L. amazonensis model, quinolines were administered orally at 25 mg/kg twice daily for 15 days. Quinolines 1, 2, 3, and 7 reduced by 80 to 90% the pa...
متن کاملCombined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum
BACKGROUND Since miltefosine monotherapy against visceral leishmaniasis (VL) caused by Leishmania donovani has been discontinued in the Indian subcontinent due to an increase in the number of treatment failures, single dose liposomal amphotericin B is now advocated as a treatment option of choice. Paromomycin-miltefosine combination therapy can be used as substitute first-line treatment in regi...
متن کاملINEFFICACY OF THE ASSOCIATION N-METHYL GLUCAMINE AND TOPICAL MILTEFOSINE IN THE TREATMENT OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS BY Leishmania (Leishmania) amazonensis
Pentavalent antimonial (Sb) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar. The aim of the present study was to compare the efficacy of glucamine (SbV) plus topical miltefosine with glucamine in the treatment of CL. Eighty isogenic C57BL/6 mice were inoculated with Leishmania (Le...
متن کاملIn vitro interaction between paromomycin sulphate and four drugs with leishmanicidal activity against three New World Leishmania species.
OBJECTIVES To evaluate in vitro interactions between paromomycin sulphate and the antileishmanial drugs meglumine antimoniate, amphotericin B, miltefosine and azithromycin against intracellular Leishmania (Leishmania) infantum chagasi, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis amastigotes in peritoneal mouse macrophages. METHODS First, drug susceptibility was a...
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تاریخ انتشار 2010